Lexus RX 350 vs. Toyota Sienna
iSeeCars' unbiased and data-driven comparison of the Lexus RX 350 and Toyota Sienna contrasts the two cars across a broad spectrum of vehicle specifications to determine which car is better. In addition to comparing pricing and specs, iSeeCars uses all the ratings, rankings, and insights from its comprehensive analyses of each vehicle model, including calculations of reliability, safety, depreciation, value retention, and the vehicle's projected lifetime recalls (based on analyzing over 25 billion data points). This in-depth evaluation is used to identify which vehicle represents a better overall choice for shoppers who are considering both the Lexus RX 350 and the Toyota Sienna.
In comparing the Lexus RX 350's and the Toyota Sienna's specifications and ratings, the Lexus RX 350 has the advantage in the areas of reliability and base engine power. The Toyota Sienna has the advantage in the areas of new vehicle base pricing, typical lower range of pricing for one- to five-year-old used cars, and fuel efficiency, resale value and overall quality score. Based on this comparison of the Lexus RX 350's and the Toyota Sienna's specifications and ratings, the Toyota Sienna is a better car than the Lexus RX 350.
Pricing: A used 2025 Lexus RX 350 ranges from $50,178 to $62,847 while a used 2025 Toyota Sienna is priced between $41,991 to $79,635. For a new model, the Lexus RX 350's price is between $52,529 and $67,035, with the Toyota Sienna priced between $43,118 and $61,879.
Resale/Retained Value: Looking at the 5-year depreciation rate for both models, the Lexus RX 350 loses 38.9 percent of its value and the Toyota Sienna loses 38.6 percent of its value. This means the Toyota Sienna retains 0.3 percentage points more of its value and has the advantage of higher resale value versus the Lexus RX 350.
Quality Rating: The iSeeCars Overall Quality rating for the Lexus RX 350 is 8.4 out of 10 while the Toyota Sienna's quality rating is 8.6 out of 10. This results in the Lexus RX 350 being ranked 3 out of 68 Best Luxury Crossover SUVs and the Toyota Sienna being ranked 1 out of 4 Best Hybrid Minivans.
Reliability Rating: iSeeCars’ Reliability Rating for the Lexus RX 350 is 8.4 out of 10. For the Toyota Sienna the reliability rating is 8.1 out of 10. This gives the Lexus RX 350 a slight advantage in reliability compared to the Toyota Sienna.
Engine Power and Fuel Efficiency Comparison: For engine performance, the Lexus RX 350’s base engine makes 275 horsepower, and the Toyota Sienna base engine makes 245 horsepower. The RX 350 is rated to deliver an average of 25 miles per gallon, with a highway range of 516 miles. The Sienna is rated to deliver an average of 36 miles per gallon, with a highway range of 648 miles. This gives the Toyota Sienna the fuel efficiency and maximum range advantage over the Lexus RX 350. The RX 350 uses premium unleaded, and the Sienna uses regular unleaded.
Safety Ratings: When comparing crash test ratings from NHTSA, the Toyota Sienna has higher safety ratings than the Lexus RX 350, with an average rating of 5 out of 5 Stars compared to 4.38 out of 5 Stars.
New Car Pricing
Asking Price:
52529 - 67035
Starting MSRP:
48975
Category Avg Starting MSRP:
(Luxury Midsize SUVs)
75104
Category Starting MSRP Range:
(Luxury Midsize SUVs)
48975 - 136200
New Car Pricing
Asking Price:
43118 - 61879
Starting MSRP:
39485
Category Avg Starting MSRP:
(Hybrid Minivans)
43780
Category Starting MSRP Range:
(Hybrid Minivans)
39485 - 51055
Used Car Pricing
Avg Used Car Price:
56207
Price Range:
50178 - 62847
Category Avg Price:
(Luxury Midsize SUVs)
82207
Category Avg Price Range:
(Luxury Midsize SUVs)
50580 - 145833
# Used Cars for Sale Nationally:
Avg Mileage of Used Cars for Sale:
# Good or Great Deals:
Used Car Pricing
Avg Used Car Price:
56023
Price Range:
41991 - 79635
Category Avg Price:
(Hybrid Minivans)
49823
Category Avg Price Range:
(Hybrid Minivans)
46024 - 56023
# Used Cars for Sale Nationally:
Avg Mileage of Used Cars for Sale:
# Good or Great Deals:
5-year Depreciation
Depreciation $:
19058
Depreciation %:
0.38914453
Resale Value $:
29917
Residual Value %:
0.61085547
Typical Category Depreciation %:
(Luxury Midsize SUVs)
0.49798776
Category Depreciation Range:
(Luxury Midsize SUVs)
0.38914453 - 0.60966222
5-year Depreciation
Depreciation $:
15099
Depreciation %:
0.38240828
Resale Value $:
24386
Residual Value %:
0.6175917200000001
Typical Category Depreciation %:
(Hybrid Minivans)
0.38240828
Category Depreciation Range:
(Hybrid Minivans)
0.38240828 - 0.38240828
Lexus RX 350 Scores & Rankings
Overall Score:
8.4 / 10
Reliability:
8.4 / 10
Retained Value:
8.5 / 10
Safety:
8.4 / 10
Toyota Sienna Scores & Rankings
Overall Score:
8.6 / 10
Reliability:
8.1 / 10
Retained Value:
8.6 / 10
Safety:
9.0 / 10
iSeeCars Reliability Insights for Lexus RX 350
Avg Life Expectancy (years):
16.8
Typical Category Life Expectancy:
(Luxury Midsize SUVs)
13.0
Category Life Expectancy Range:
(Luxury Midsize SUVs)
9.7 - 16.8
Chance of Reaching 200k Miles for a New Car:
0.335
iSeeCars Reliability Insights for Toyota Sienna
Avg Life Expectancy (years):
Typical Category Life Expectancy:
N/A
Category Life Expectancy Range:
N/A
Chance of Reaching 200k Miles for a New Car:
Expected 30-year Lifetime Recalls
Expected Lifetime Recalls:
1.6058349948310648
Typical Category Recalls:
(Luxury Midsize SUVs)
2.7
Category Range for Recalls:
(Luxury Midsize SUVs)
1.4 - 15.4
Expected 30-year Lifetime Recalls
Expected Lifetime Recalls:
4.486332752729129
Typical Category Recalls:
(Hybrid Minivans)
3.0
Category Range for Recalls:
(Hybrid Minivans)
2.8 - 4.5
Lexus RX 350 Rankings
Ranking
1 out of / 68Ranking
1 out of / 27Ranking
1 out of / 27Ranking
1 out of / 25Ranking
1 out of / 25Ranking
1 out of / 1Ranking
3 out of / 68Ranking
3 out of / 27Ranking
4 out of / 68Ranking
5 out of / 5Ranking
12 out of / 27Ranking
15 out of / 27Ranking
16 out of / 27Ranking
19 out of / 27Ranking
21 out of / 27Ranking
24 out of / 64Ranking
24 out of / 27Ranking
27 out of / 27Ranking
28 out of / 68Ranking
34 out of / 68Ranking
34 out of / 68Ranking
36 out of / 68Ranking
41 out of / 68Ranking
41 out of / 68Ranking
65 out of / 68Toyota Sienna Rankings
Ranking
1 out of / 25Ranking
1 out of / 25Ranking
1 out of / 4Ranking
1 out of / 4Ranking
1 out of / 4Ranking
1 out of / 4Ranking
1 out of / 4Ranking
1 out of / 4Ranking
1 out of / 4Ranking
1 out of / 3Ranking
1 out of / 1Ranking
1 out of / 1Ranking
2 out of / 25Ranking
2 out of / 25Ranking
2 out of / 25Ranking
2 out of / 25Ranking
2 out of / 4Ranking
2 out of / 4Ranking
3 out of / 25Ranking
3 out of / 4Ranking
4 out of / 25Ranking
4 out of / 25Ranking
4 out of / 25Ranking
4 out of / 4Ranking
4 out of / 4Ranking
9 out of / 25Ranking
12 out of / 25Ranking
12 out of / 15Ranking
13 out of / 25Available Body Styles
SUV
Available Body Styles
Minivan
Available Drivetrain Options
Gasoline
Available Drivetrain Options
Hybrid
Lexus RX 350 Trim Levels
Base, F SPORT Design, F SPORT Handling, Luxury, Premium, Premium+
Toyota Sienna Trim Levels
LE 8-Passenger, Limited 7-Passenger, Platinum 7-Passenger, Woodland Edition, XLE 7-Passenger, XLE 8-Passenger, XSE 7-Passenger
Warranty Information
Warranty, Bumper-to-Bumper:
4 years / 50000 miles
Warranty, Powertrain:
6 years / 70000 miles
Warranty, Roadside Assistance:
4 years
Warranty Information
Warranty, Bumper-to-Bumper:
3 years / 36000 miles
Warranty, Powertrain:
5 years / 60000 miles
Warranty, Roadside Assistance:
2 years
Safety Ratings
NHTSA Safety Rating (last 5 year average):
4.38 out of 5 Stars
2025 NHTSA Overall Rating:
4 out of 5 Stars
2025 NHTSA Front Crash Overall Rating:
4 out of 5 Stars
2025 NHTSA Side Crash Overall Rating:
5 out of 5 Stars
2025 NHTSA Rollover Rating:
4 out of 5 Stars
IIHS Safety Rating:
Not yet available
Safety Ratings
NHTSA Safety Rating (last 5 year average):
5 out of 5 Stars
2025 NHTSA Overall Rating:
4 out of 5 Stars
2025 NHTSA Front Crash Overall Rating:
4 out of 5 Stars
2025 NHTSA Side Crash Overall Rating:
5 out of 5 Stars
2025 NHTSA Rollover Rating:
4 out of 5 Stars
IIHS Safety Rating:
Not yet available
Base Drivetrain Specs
Horsepower:
275 hp @ 6000 rpm
Torque:
317 foot-lbs @ 1700 rpm
Power-to-Weight Ratio (higher is better):
0.066 hp per pound
Towing capacity:
Not yet available
Base Drivetrain Specs
Horsepower:
245 hp @ 6000 rpm
Torque:
Not yet available
Power-to-Weight Ratio (higher is better):
0.053 hp per pound
Towing capacity:
Not yet available
Engine Specifications
Engine Size:
2.4 liters
Engine Configuration:
Inline
Number of Cylinders:
4
Transmission:
Automatic
Standard/Optional Drivetrain Type:
FWD / AWD
EPA Fuel Economy
(City/Highway/Combined MPG):
22 / 29 / 25
Range (city/hwy):
392 / 516 miles
Recommended Fuel Type:
Premium Unleaded
Engine Specifications
Engine Size:
2.5 liters
Engine Configuration:
Inline
Number of Cylinders:
4
Transmission:
Continuously Variable Transmission (CVT Automatic)
Standard/Optional Drivetrain Type:
FWD / AWD
EPA Fuel Economy
(City/Highway/Combined MPG):
36 / 36 / 36
Range (city/hwy):
648 / 648 miles
Recommended Fuel Type:
Regular Unleaded
Standard/Optional Features
Adaptive Cruise Control:
Standard
Alloy wheels:
Standard
Android Auto:
Standard
Apple CarPlay:
Standard
Bench Seats:
Standard
Bluetooth:
Standard
Heated Seats
Standard
Internet Radio:
Standard
Keyless Entry:
Standard
Keyless Ignition:
Standard
Leather Upholstery:
Standard
Navigation System:
Standard
Paddle Shifters:
Standard
Parking Sensors:
Standard
Power Lift Gate:
Standard
Power outlet:
Standard
Roadside assistance:
Standard
Satellite radio:
Standard
Voice Recognition:
Standard
Wifi:
Standard
Automatic Parking:
Available
Cooled/Ventilated Seats:
Available
Heated Steering Wheel:
Available
Roof Rack:
Available
Sunroof/Moonroof:
Available
Trailer Hitch:
Available
Wireless Smartphone Charging:
Available
Air Suspension:
N/A
Captain's seat:
N/A
Front Bench Seats:
N/A
Massage Seats:
N/A
Panoramic Sunroof/Moonroof
N/A
Quad Seats:
N/A
Standard/Optional Features
Adaptive Cruise Control:
Standard
Alloy wheels:
Standard
Android Auto:
Standard
Apple CarPlay:
Standard
Bench Seats:
Standard
Bluetooth:
Standard
Heated Seats
Available
Internet Radio:
Standard
Keyless Entry:
Standard
Keyless Ignition:
Standard
Leather Upholstery:
Available
Navigation System:
Available
Paddle Shifters:
N/A
Parking Sensors:
Available
Power Lift Gate:
Available
Power outlet:
Standard
Roadside assistance:
Standard
Satellite radio:
Standard
Voice Recognition:
Standard
Wifi:
Standard
Automatic Parking:
N/A
Cooled/Ventilated Seats:
Available
Heated Steering Wheel:
Available
Roof Rack:
Available
Sunroof/Moonroof:
Available
Trailer Hitch:
Available
Wireless Smartphone Charging:
Standard
Air Suspension:
N/A
Captain's seat:
Standard
Front Bench Seats:
N/A
Massage Seats:
N/A
Panoramic Sunroof/Moonroof
N/A
Quad Seats:
Available
Safety Features
Backup camera:
Standard
Blind Spot Monitoring:
Standard
Forward Collision Warning:
Standard
Lane Departure Warning:
Standard
Lane Keeping Assist:
Standard
Pedestrian Detection:
Standard
Rear Cross-Traffic Alert:
Standard
Rear Seat Reminder:
Standard
360-Degree Camera:
N/A
Driver Attention Monitoring:
N/A
Safety Features
Backup camera:
Standard
Blind Spot Monitoring:
Standard
Forward Collision Warning:
Standard
Lane Departure Warning:
Standard
Lane Keeping Assist:
Standard
Pedestrian Detection:
Standard
Rear Cross-Traffic Alert:
Standard
Rear Seat Reminder:
Standard
360-Degree Camera:
Available
Driver Attention Monitoring:
N/A
Interior Dimensions
Front Head Room:
39.5 inches
Front Leg Room:
41.1 inches
Front Shoulder Room:
58.1 inches
Rear Head Room:
38.6 inches
Rear Leg Room:
37.4 inches
Rear Shoulder Room:
56.5 inches
Cargo Space:
29.6 cubic feet
Cargo Space, 2nd-row seat folded down:
46.2 cubic feet
Cargo Space, 3rd-row seat folded down:
Not applicable
Overall Interior Volume:
Not yet available
Interior Dimensions
Front Head Room:
40.1 inches
Front Leg Room:
40.3 inches
Front Shoulder Room:
62.4 inches
Rear Head Room:
39.3 inches
Rear Leg Room:
39.9 inches
Rear Shoulder Room:
62.7 inches
Cargo Space:
33.5 cubic feet
Cargo Space, 2nd-row seat folded down:
101 cubic feet
Cargo Space, 3rd-row seat folded down:
Not applicable
Overall Interior Volume:
195.9 cubic feet
Exterior Dimensions
Curb Weight:
4155 lbs
Width:
75.6 inches
Height:
67.3 inches
Length:
192.5 inches
Wheelbase:
112.2 inches
Ground Clearance:
8.2 inches
Exterior Dimensions
Curb Weight:
4610 lbs
Width:
78.5 inches
Height:
68.5 inches
Length:
203.7 inches
Wheelbase:
120.5 inches
Ground Clearance:
6.4 inches
Standard Wheel/Tire Information
Wheel Size:
19.0 x 8.0 inches
Wheel Type:
aluminum alloy
Tire Size:
235/60R19
Standard Wheel/Tire Information
Wheel Size:
17.0 x 7.0 inches
Wheel Type:
aluminum alloy
Tire Size:
P235/65R17
Exterior Colors
Black
Caviar
Blue
Nightfall Mica
Gray
Cloudburst Gray
Green
Nori Green Pearl
Red
Matador Red Mica
Silver
Iridium
White
Eminent White Pearl
Exterior Colors
Black
Midnight Black Metallic
Blue
Blueprint
Gray
Magnetic Gray Metallic
Green
Cypress
Red
Ruby Flare Pearl
Silver
Celestial Silver Metallic
White
Ice Cap
Interior Colors
Black
Black w/ Black Cascade Trim
Brown
Palamino w/ Black Cascade Trim
Gray
Not available
Interior Colors
Black
Not available
Brown
Not available
Gray
Gray
