Lexus RX 350 vs. Acura MDX
iSeeCars' unbiased and data-driven comparison of the Lexus RX 350 and Acura MDX contrasts the two cars across a broad spectrum of vehicle specifications to determine which car is better. In addition to comparing pricing and specs, iSeeCars uses all the ratings, rankings, and insights from its comprehensive analyses of each vehicle model, including calculations of reliability, safety, depreciation, value retention, and the vehicle's projected lifetime recalls (based on analyzing over 25 billion data points). This in-depth evaluation is used to identify which vehicle represents a better overall choice for shoppers who are considering both the Lexus RX 350 and the Acura MDX.
When we compare the Lexus RX 350's and the Acura MDX's specifications and ratings, the Lexus RX 350 has the advantage in the areas of new vehicle base pricing, typical lower range of pricing for one- to five-year-old used cars, reliability and resale value. The Acura MDX has the advantage in the areas of overall quality score and base engine power. Based on this comparison of the Lexus RX 350's and the Acura MDX's specifications and ratings, the Lexus RX 350 is a better car than the Acura MDX.
Pricing: A used 2025 Lexus RX 350 ranges from $50,178 to $62,847 while a used 2026 Acura MDX is priced between $55,350 to $70,850. For a new model, the Lexus RX 350's price is between $52,529 and $67,035, with the Acura MDX priced between $55,950 and $77,785.
Resale/Retained Value: Looking at the 5-year depreciation rate for both models, the Lexus RX 350 loses 38.9 percent of its value and the Acura MDX loses 53.7 percent of its value. This means the Lexus RX 350 retains 14.8 percentage points more of its value and has the advantage of higher resale value versus the Acura MDX.
Quality Rating: The iSeeCars Overall Quality rating for the Lexus RX 350 is 8.4 out of 10 while the Acura MDX's quality rating is 8.5 out of 10. This results in the Lexus RX 350 being ranked 5 out of 27 Best Luxury Midsize SUVs and the Acura MDX being ranked 3 out of 27. Out of 68 Best Luxury Crossover SUVs, the Lexus RX 350 is ranked 9 and the Acura MDX is ranked 6.
Reliability Rating: iSeeCars’ Reliability Rating for the Lexus RX 350 is 8.4 out of 10. For the Acura MDX the reliability rating is 8.0 out of 10. This gives the Lexus RX 350 a slight advantage in reliability compared to the Acura MDX.
Engine Power and Fuel Efficiency Comparison: For engine performance, the Lexus RX 350’s base engine makes 275 horsepower, and the Acura MDX base engine makes 290 horsepower.
Safety Ratings: When comparing crash test ratings from NHTSA, the Acura MDX has higher safety ratings than the Lexus RX 350, with an average rating of 5 out of 5 Stars compared to 4.38 out of 5 Stars.
New Car Pricing
Asking Price:
52529 - 67035
Starting MSRP:
48975
Category Avg Starting MSRP:
(Luxury Midsize SUVs)
75104
Category Starting MSRP Range:
(Luxury Midsize SUVs)
48975 - 136200
New Car Pricing
Asking Price:
55950 - 77785
Starting MSRP:
51800
Category Avg Starting MSRP:
(Luxury Midsize SUVs)
77833
Category Starting MSRP Range:
(Luxury Midsize SUVs)
51200 - 138300
Used Car Pricing
Avg Used Car Price:
56207
Price Range:
50178 - 62847
Category Avg Price:
(Luxury Midsize SUVs)
82207
Category Avg Price Range:
(Luxury Midsize SUVs)
50580 - 145833
# Used Cars for Sale Nationally:
Avg Mileage of Used Cars for Sale:
# Good or Great Deals:
Used Car Pricing
Avg Used Car Price:
66659
Price Range:
55350 - 70850
Category Avg Price:
(Luxury Midsize SUVs)
73712
Category Avg Price Range:
(Luxury Midsize SUVs)
60234 - 92425
# Used Cars for Sale Nationally:
Avg Mileage of Used Cars for Sale:
# Good or Great Deals:
5-year Depreciation
Depreciation $:
19058
Depreciation %:
0.38914453
Resale Value $:
29917
Residual Value %:
0.61085547
Typical Category Depreciation %:
(Luxury Midsize SUVs)
0.49798776
Category Depreciation Range:
(Luxury Midsize SUVs)
0.38914453 - 0.60966222
5-year Depreciation
Depreciation $:
27937
Depreciation %:
0.53931912
Resale Value $:
23863
Residual Value %:
0.46068087999999996
Typical Category Depreciation %:
(Luxury Midsize SUVs)
0.56208052
Category Depreciation Range:
(Luxury Midsize SUVs)
0.41556056 - 0.61479035
Lexus RX 350 Scores & Rankings
Overall Score:
8.4 / 10
Reliability:
8.4 / 10
Retained Value:
8.5 / 10
Safety:
8.4 / 10
Acura MDX Scores & Rankings
Overall Score:
8.5 / 10
Reliability:
8.0 / 10
Retained Value:
7.6 / 10
Safety:
10.0 / 10
iSeeCars Reliability Insights for Lexus RX 350
Avg Life Expectancy (years):
16.8
Typical Category Life Expectancy:
(Luxury Midsize SUVs)
13.0
Category Life Expectancy Range:
(Luxury Midsize SUVs)
9.7 - 16.8
Chance of Reaching 200k Miles for a New Car:
0.335
iSeeCars Reliability Insights for Acura MDX
Avg Life Expectancy (years):
13.1
Typical Category Life Expectancy:
(Luxury Midsize SUVs)
12.8
Category Life Expectancy Range:
(Luxury Midsize SUVs)
9.7 - 13.1
Chance of Reaching 200k Miles for a New Car:
0.317
Expected 30-year Lifetime Recalls
Expected Lifetime Recalls:
1.6058349948310648
Typical Category Recalls:
(Luxury Midsize SUVs)
2.7
Category Range for Recalls:
(Luxury Midsize SUVs)
1.4 - 15.4
Expected 30-year Lifetime Recalls
Expected Lifetime Recalls:
Typical Category Recalls:
N/A
Category Range for Recalls:
N/A
Lexus RX 350 Rankings
Ranking
1 out of / 27Ranking
1 out of / 27Ranking
1 out of / 23Ranking
1 out of / 23Ranking
1 out of / 13Ranking
1 out of / 7Ranking
2 out of / 68Ranking
2 out of / 27Ranking
2 out of / 7Ranking
3 out of / 13Ranking
4 out of / 68Ranking
5 out of / 27Ranking
9 out of / 68Ranking
11 out of / 27Ranking
12 out of / 27Ranking
14 out of / 68Ranking
14 out of / 27Ranking
15 out of / 27Ranking
16 out of / 27Ranking
21 out of / 27Ranking
24 out of / 27Ranking
27 out of / 27Ranking
29 out of / 60Ranking
30 out of / 68Ranking
31 out of / 68Ranking
33 out of / 68Ranking
36 out of / 68Ranking
36 out of / 68Ranking
38 out of / 68Ranking
42 out of / 68Ranking
65 out of / 68Acura MDX Rankings
Ranking
1 out of / 7Ranking
1 out of / 6Ranking
2 out of / 13Ranking
2 out of / 6Ranking
3 out of / 29Ranking
3 out of / 27Ranking
3 out of / 27Ranking
3 out of / 23Ranking
3 out of / 23Ranking
3 out of / 13Ranking
3 out of / 7Ranking
4 out of / 29Ranking
5 out of / 29Ranking
5 out of / 27Ranking
5 out of / 26Ranking
6 out of / 68Ranking
6 out of / 29Ranking
6 out of / 27Ranking
7 out of / 68Ranking
8 out of / 29Ranking
9 out of / 68Ranking
9 out of / 29Ranking
9 out of / 27Ranking
9 out of / 27Ranking
10 out of / 27Ranking
12 out of / 27Ranking
13 out of / 68Ranking
13 out of / 68Ranking
14 out of / 27Ranking
17 out of / 29Ranking
17 out of / 27Ranking
18 out of / 29Ranking
19 out of / 68Ranking
19 out of / 27Ranking
19 out of / 27Ranking
21 out of / 29Ranking
22 out of / 29Ranking
22 out of / 29Ranking
23 out of / 68Ranking
23 out of / 29Ranking
23 out of / 27Ranking
24 out of / 29Ranking
27 out of / 68Ranking
32 out of / 60Ranking
33 out of / 68Ranking
36 out of / 68Ranking
41 out of / 68Ranking
49 out of / 68Ranking
51 out of / 68Available Body Styles
SUV
Available Body Styles
SUV
Available Drivetrain Options
Gasoline
Available Drivetrain Options
Gasoline
Lexus RX 350 Trim Levels
Base, F SPORT Design, F SPORT Handling, Luxury, Premium, Premium+
Acura MDX Trim Levels
Base, SH-AWD, SH-AWD w/A-SPEC w/Advance, SH-AWD Type S w/Advance Package, SH-AWD w/A-SPEC, SH-AWD w/Advance, SH-AWD w/Tech, w/Tech
Warranty Information
Warranty, Bumper-to-Bumper:
4 years / 50000 miles
Warranty, Powertrain:
6 years / 70000 miles
Warranty, Roadside Assistance:
4 years
Warranty Information
Warranty, Bumper-to-Bumper:
4 years / 50000 miles
Warranty, Powertrain:
6 years / 70000 miles
Warranty, Roadside Assistance:
4 years / 50000 miles
Safety Ratings
NHTSA Safety Rating (last 5 year average):
4.38 out of 5 Stars
2026 NHTSA Overall Rating:
4 out of 5 Stars
2026 NHTSA Front Crash Overall Rating:
4 out of 5 Stars
2026 NHTSA Side Crash Overall Rating:
5 out of 5 Stars
2026 NHTSA Rollover Rating:
4 out of 5 Stars
IIHS Safety Rating:
Not yet available
Safety Ratings
NHTSA Safety Rating (last 5 year average):
5 out of 5 Stars
2026 NHTSA Overall Rating:
Not yet available
2026 NHTSA Front Crash Overall Rating:
Not yet available
2026 NHTSA Side Crash Overall Rating:
Not yet available
2026 NHTSA Rollover Rating:
Not yet available
IIHS Safety Rating:
Not yet available
Base Drivetrain Specs
Horsepower:
275 hp @ 6000 rpm
Torque:
317 foot-lbs @ 1700 rpm
Power-to-Weight Ratio (higher is better):
0.066 hp per pound
Towing capacity:
Not yet available
Base Drivetrain Specs
Horsepower:
290 hp @ 6200 rpm
Torque:
267 foot-lbs @ 4700 rpm
Power-to-Weight Ratio (higher is better):
0.068 hp per pound
Towing capacity:
Not yet available
Engine Specifications
Engine Size:
2.4 liters
Engine Configuration:
Inline
Number of Cylinders:
4
Transmission:
Automatic
Standard/Optional Drivetrain Type:
FWD / AWD
EPA Fuel Economy
(City/Highway/Combined MPG):
22 / 29 / 25
Range (city/hwy):
392 / 516 miles
Recommended Fuel Type:
Premium Unleaded
Engine Specifications
Engine Size:
3.5 liters
Engine Configuration:
V
Number of Cylinders:
6
Transmission:
Automatic
Standard/Optional Drivetrain Type:
FWD / AWD
EPA Fuel Economy
(City/Highway/Combined MPG):
Not yet available
Range (city/hwy):
Not yet available
Recommended Fuel Type:
Not yet available
Standard/Optional Features
Adaptive Cruise Control:
Standard
Alloy wheels:
Standard
Android Auto:
Standard
Apple CarPlay:
Standard
Bench Seats:
Standard
Bluetooth:
Standard
Heated Seats
Standard
Internet Radio:
Standard
Keyless Entry:
Standard
Keyless Ignition:
Standard
Leather Upholstery:
Standard
Navigation System:
Standard
Paddle Shifters:
Standard
Parking Sensors:
Standard
Power Lift Gate:
Standard
Power outlet:
Standard
Roadside assistance:
Standard
Satellite radio:
Standard
Voice Recognition:
Standard
Wifi:
Standard
Automatic Parking:
Available
Cooled/Ventilated Seats:
Available
Heated Steering Wheel:
Available
Roof Rack:
Available
Sunroof/Moonroof:
Available
Trailer Hitch:
Available
Wireless Smartphone Charging:
Available
Air Suspension:
N/A
Captain's seat:
N/A
Front Bench Seats:
N/A
Massage Seats:
N/A
Panoramic Sunroof/Moonroof
N/A
Quad Seats:
N/A
Standard/Optional Features
Adaptive Cruise Control:
Standard
Alloy wheels:
Standard
Android Auto:
Standard
Apple CarPlay:
Standard
Bench Seats:
Standard
Bluetooth:
Standard
Heated Seats
Standard
Internet Radio:
N/A
Keyless Entry:
Standard
Keyless Ignition:
Standard
Leather Upholstery:
Standard
Navigation System:
Standard
Paddle Shifters:
Standard
Parking Sensors:
Available
Power Lift Gate:
Standard
Power outlet:
Standard
Roadside assistance:
Standard
Satellite radio:
N/A
Voice Recognition:
Standard
Wifi:
Standard
Automatic Parking:
N/A
Cooled/Ventilated Seats:
Available
Heated Steering Wheel:
Available
Roof Rack:
Available
Sunroof/Moonroof:
Standard
Trailer Hitch:
Available
Wireless Smartphone Charging:
Standard
Air Suspension:
Available
Captain's seat:
N/A
Front Bench Seats:
N/A
Massage Seats:
Available
Panoramic Sunroof/Moonroof
N/A
Quad Seats:
N/A
Safety Features
Backup camera:
Standard
Blind Spot Monitoring:
Standard
Forward Collision Warning:
Standard
Lane Departure Warning:
Standard
Lane Keeping Assist:
Standard
Pedestrian Detection:
Standard
Rear Cross-Traffic Alert:
Standard
Rear Seat Reminder:
Standard
360-Degree Camera:
N/A
Driver Attention Monitoring:
N/A
Safety Features
Backup camera:
Standard
Blind Spot Monitoring:
Standard
Forward Collision Warning:
Standard
Lane Departure Warning:
Standard
Lane Keeping Assist:
Standard
Pedestrian Detection:
Standard
Rear Cross-Traffic Alert:
Standard
Rear Seat Reminder:
Standard
360-Degree Camera:
Available
Driver Attention Monitoring:
Standard
Interior Dimensions
Front Head Room:
39.5 inches
Front Leg Room:
41.1 inches
Front Shoulder Room:
58.1 inches
Rear Head Room:
38.6 inches
Rear Leg Room:
37.4 inches
Rear Shoulder Room:
56.5 inches
Cargo Space:
29.6 cubic feet
Cargo Space, 2nd-row seat folded down:
46.2 cubic feet
Overall Interior Volume:
Not yet available
Interior Dimensions
Front Head Room:
38.5 inches
Front Leg Room:
41.6 inches
Front Shoulder Room:
61.9 inches
Rear Head Room:
38.1 inches
Rear Leg Room:
38.5 inches
Rear Shoulder Room:
60.3 inches
Cargo Space:
16.3 cubic feet
Cargo Space, 2nd-row seat folded down:
71.4 cubic feet
Overall Interior Volume:
155.4 cubic feet
Exterior Dimensions
Curb Weight:
4155 lbs
Width:
75.6 inches
Height:
67.3 inches
Length:
192.5 inches
Wheelbase:
112.2 inches
Ground Clearance:
8.2 inches
Exterior Dimensions
Curb Weight:
4268 lbs
Width:
78.7 inches
Height:
67.9 inches
Length:
198.4 inches
Wheelbase:
113.8 inches
Ground Clearance:
7.3 inches
Standard Wheel/Tire Information
Wheel Size:
19.0 x 8.0 inches
Wheel Type:
aluminum alloy
Tire Size:
235/60R19
Standard Wheel/Tire Information
Wheel Size:
19.0 x 8.5 inches
Wheel Type:
aluminum alloy
Tire Size:
255/55R19
Exterior Colors
Black
Caviar
Blue
Nightfall Mica
Gray
Cloudburst Gray
Green
Nori Green Pearl
Red
Matador Red Mica
Silver
Iridium
White
Eminent White Pearl
Exterior Colors
Black
Majestic Black Pearl
Blue
Not available
Gray
Liquid Carbon Metallic
Green
Not available
Red
Not available
Silver
Solar Silver Metallic
White
Platinum White Pearl
Interior Colors
Black
Black w/ Black Cascade Trim
Brown
Palamino w/ Black Cascade Trim
Beige
Not available
Interior Colors
Black
Ebony
Brown
Not available
Beige
Parchment
