Acura TLX vs. Lexus ES 350

iSeeCars' unbiased and data-driven comparison of the Acura TLX and Lexus ES 350 contrasts the two cars across a broad spectrum of vehicle specifications to determine which car is better. In addition to comparing pricing and specs, iSeeCars uses all the ratings, rankings, and insights from its comprehensive analyses of each vehicle model, including calculations of reliability, safety, depreciation, value retention, and the vehicle's projected lifetime recalls (based on analyzing over 25 billion data points). This in-depth evaluation is used to identify which vehicle represents a better overall choice for shoppers who are considering both the Acura TLX and the Lexus ES 350.

When comparing the Acura TLX's and the Lexus ES 350's specifications and ratings, the Acura TLX has the advantage in the area of typical lower range of pricing for one- to five-year-old used cars. The Lexus ES 350 has the advantage in the areas of new vehicle base pricing, reliability, resale value, interior volume, overall quality score and base engine power. The Acura TLX and Lexus ES 350 have the same fuel efficiency. Based on this comparison of the Acura TLX's and the Lexus ES 350's specifications and ratings, the Lexus ES 350 is a better car than the Acura TLX.

Pricing: A used 2025 Acura TLX ranges from $36,988 to $52,195 while a used 2025 Lexus ES 350 is priced between $39,995 to $53,481. For a new model, the Acura TLX's price is between $46,595 and $59,845, with the Lexus ES 350 priced between $45,876 and $56,904.

Resale/Retained Value: Looking at the 5-year depreciation rate for both models, the Acura TLX loses 49.7 percent of its value and the Lexus ES 350 loses 42.1 percent of its value. This means the Lexus ES 350 retains 7.6 percentage points more of its value and has the advantage of higher resale value versus the Acura TLX.

Quality Rating: The iSeeCars Overall Quality rating for the Acura TLX is 7.8 out of 10 while the Lexus ES 350's quality rating is 8.4 out of 10. This results in the Acura TLX being ranked 8 out of 24 Best Luxury Midsize Cars and the Lexus ES 350 being ranked 1 out of 24.

Reliability Rating: iSeeCars’ Reliability Rating for the Acura TLX is 7.7 out of 10. For the Lexus ES 350 the reliability rating is 7.9 out of 10. This gives the Lexus ES 350 a slight advantage in reliability compared to the Acura TLX.

Engine Power and Fuel Efficiency Comparison: For engine performance, the Acura TLX’s base engine makes 272 horsepower, and the Lexus ES 350 base engine makes 302 horsepower. The TLX is rated to deliver an average of 25 miles per gallon, with a highway range of 491 miles. The ES 350 is rated to deliver an average of 25 miles per gallon, with a highway range of 509 miles. This gives the Lexus ES 350 the fuel efficiency and maximum range advantage over the Acura TLX. The TLX uses premium unleaded, and the ES 350 uses regular unleaded.

Passenger Space Comparison: While both models are midsize cars, the Lexus ES 350 has the advantage of offering more interior volume, reflected in more front head room, rear head room, rear leg room, and cargo space. The Acura TLX has the advantage in the areas of front shoulder room, front leg room and rear shoulder room.

Safety Ratings: When comparing crash test ratings from NHTSA, both the Acura TLX and the Lexus ES 350 have the same average safety rating of 5 out of 5 Stars.