Page Loading

Best Luxury Midsize Cars for 2022

The best used and new luxury midsize cars based on a data-driven analysis of each vehicle's reliability, resale value and safety.

The best luxury midsize car is the Lexus ES 350 based on our analysis of 12 million vehicles to assess their reliability, resale value and safety. Its overall rating of 9.2 out of 10 reflects the ES 350’s reliability, value retention and safety scores. A new Lexus ES 350 costs between $40,950 and $50,130 while a used version costs between $28,331 and $46,998. This luxury midsize car can seat up to 5 people and is EPA rated to deliver up to 26 miles per gallon in mixed city/highway driving.

The Luxury Midsize Car category consists of 29 models priced between $25,370 and $142,000 for new vehicles and between $18,964 and $153,400 for used vehicles. iSeeCars has sufficient vehicle data to rate and rank 17 of these 29 models based on their reliability, value retention and safety scores.

See more

The best luxury midsize car is the Lexus ES 350 based on our analysis of 12 million vehicles to assess their reliability, resale value and safety. Its overall rating of 9.2 out of 10 reflects the ES 350’s reliability, value retention and safety scores. A new Lexus ES 350 costs between $40,950 and $50,130 while a used version costs between $28,331 and $46,998. This luxury midsize car can seat up to 5 people and is EPA rated to deliver up to 26 miles per gallon in mixed city/highway driving.

The Luxury Midsize Car category consists of 29 models priced between $25,370 and $142,000 for new vehicles and between $18,964 and $153,400 for used vehicles. iSeeCars has sufficient vehicle data to rate and rank 17 of these 29 models based on their reliability, value retention and safety scores.

See more

1. Lexus ES 350

#1 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
9.2 / 10
  • Reliability 8.9 / 10
  • Value Retention 8.9 / 10
  • Safety 10 / 10

2. Lexus GS 350

#2 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
8.8 / 10
  • Reliability 8.9 / 10
  • Value Retention 8.6 / 10
  • Safety Not Available

3. Lincoln MKZ

#6 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
8.7 / 10
  • Reliability 8.5 / 10
  • Value Retention 7.5 / 10
  • Safety 10 / 10

4. Mercedes-Benz E-Class Sedan

#3 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
8.5 / 10
  • Reliability 8.7 / 10
  • Value Retention 6.9 / 10
  • Safety 10 / 10

5. Audi A6

#5 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
8.4 / 10
  • Reliability 8.6 / 10
  • Value Retention 6.6 / 10
  • Safety 10 / 10

6. Audi S6

#8 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
8.4 / 10
  • Reliability 7.8 / 10
  • Value Retention 7.5 / 10
  • Safety 10 / 10

7. Acura TLX

#12 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
8.4 / 10
  • Reliability 7.2 / 10
  • Value Retention 7.9 / 10
  • Safety 10 / 10

8. Volvo S90

#13 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
8.1 / 10
  • Reliability 7.2 / 10
  • Value Retention 6.9 / 10
  • Safety 10 / 10

9. Lexus LC 500

#15 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
8.1 / 10
  • Reliability 7.0 / 10
  • Value Retention 9.1 / 10
  • Safety Not Available

10. Genesis G80

#16 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
8.0 / 10
  • Reliability 5.9 / 10
  • Value Retention 8.0 / 10
  • Safety 10 / 10

11. BMW M5

#7 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
7.9 / 10
  • Reliability 8.4 / 10
  • Value Retention 7.4 / 10
  • Safety Not Available

12. Lexus GS F

#14 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
7.9 / 10
  • Reliability 7.2 / 10
  • Value Retention 8.6 / 10
  • Safety Not Available

13. BMW 5 Series

#4 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
7.8 / 10
  • Reliability 8.7 / 10
  • Value Retention 7.0 / 10
  • Safety Not Available

14. Mercedes-Benz E-Class Coupe

#9 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
7.8 / 10
  • Reliability 7.7 / 10
  • Value Retention 7.9 / 10
  • Safety Not Available

15. Audi S7

#11 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
7.3 / 10
  • Reliability 7.3 / 10
  • Value Retention 7.4 / 10
  • Safety Not Available

16. Jaguar XF

#10 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
7.3 / 10
  • Reliability 7.7 / 10
  • Value Retention 6.9 / 10
  • Safety Not Available

17. Maserati Ghibli

#17 of 29 Most Reliable Luxury Midsize Cars
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
6.3 / 10
  • Reliability 5.9 / 10
  • Value Retention 6.8 / 10
  • Safety Not Available
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
Coming soon
  • Reliability Coming soon
  • Value Retention 8.7 / 10
  • Safety 10 / 10
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
Coming soon
  • Reliability Coming soon
  • Value Retention 8.7 / 10
  • Safety Not Available
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
Coming soon
  • Reliability Coming soon
  • Value Retention 8.4 / 10
  • Safety Not Available
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
Coming soon
  • Reliability Coming soon
  • Value Retention 7.6 / 10
  • Safety Not Available
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
Coming soon
  • Reliability Coming soon
  • Value Retention 7.3 / 10
  • Safety 10 / 10
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
Coming soon
  • Reliability Coming soon
  • Value Retention 7.3 / 10
  • Safety Not Available
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
Coming soon
  • Reliability Coming soon
  • Value Retention 7.2 / 10
  • Safety Not Available
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
Coming soon
  • Reliability Coming soon
  • Value Retention 7.1 / 10
  • Safety Not Available
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
Coming soon
  • Reliability Coming soon
  • Value Retention 7.1 / 10
  • Safety Not Available
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
Coming soon
  • Reliability Coming soon
  • Value Retention 7.1 / 10
  • Safety Not Available
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
Coming soon
  • Reliability Coming soon
  • Value Retention 7.0 / 10
  • Safety Not Available
iSEECARS SCORE

iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association

See how we rank these cars
Coming soon
  • Reliability Coming soon
  • Value Retention 6.6 / 10
  • Safety 10 / 10

How We Rank These Cars

iSeeCars Best Car Rankings are calculated based on the latest research by our data science team and the National Highway Traffic Safety Administration (NHTSA).

We analyze data from over 12 million new and used vehicles in our Longest-Lasting Cars and 5-Year Depreciation Studies, combined with the NHTSA's Safety Ratings to give you an unbiased guide to the best vehicles in each segment.

After being evaluated, vehicles with the highest average scores earn a spot in the iSeeCars Best Car Rankings. (No final score is given to vehicles missing a score in any of the categories, but scores for other categories are still shown.)

Vehicles are scored in three categories:

Reliability | 33.3%

The reliability score represents an analysis of iSeeCars' proprietary research on the longest-lasting vehicles.

Value Retention | 33.3%

The value retention score is based on our data science team's statistical analysis and prediction of 5-year depreciation from MSRP to determine which cars hold their value best, using US Bureau of Labor Statistics data to adjust for inflation.

Safety | 33.3%

The safety score is calculated based on the last five years of crash test ratings from the National Highway Traffic Safety Administration (NHTSA) and incorporates the latest Top Safety Pick information from the Insurance Institute for Highway Safety (IIHS).