Best Gas Mileage Luxury Midsize Cars for 2024
Our analysis of the luxury midsize cars with the best gas mileage ranks them based on the highest mpg and most fuel-efficient drivetrain for each vehicle.
The BMW 5 Series sedan non-hybrid/electric is the most fuel-efficient luxury midsize car with an EPA rating of 30 MPG. The second-ranked Lexus ES 250 sedan non-hybrid/electric also earns 28 MPG, while the third-ranked Mercedes-Benz E-Class sedan non-hybrid/electric earns 27 MPG. When two or more vehicles have the same MPG rating they are then ranked by their overall quality score, as shown below. iSeeCars has ranked 20 luxury midsize cars based on fuel efficiency. This ranking is based on each model's highest-rated combined MPG figure to determine the best gas mileage luxury midsize cars.
The average fuel efficiency for a luxury midsize car is 24 MPG, and 13 models earn that figure or better for their highest-rated combined MPG model. A luxury midsize car with less than 24 combined MPG is below the segment average and may not be a good model for consumers seeking to reduce or manage their fuel consumption.
The BMW 5 Series sedan non-hybrid/electric is the most fuel-efficient luxury midsize car with an EPA rating of 30 MPG. The second-ranked Lexus ES 250 sedan non-hybrid/electric also earns 28 MPG, while the third-ranked Mercedes-Benz E-Class sedan non-hybrid/electric earns 27 MPG. When two or more vehicles have the same MPG rating they are then ranked by their overall quality score, as shown below. iSeeCars has ranked 20 luxury midsize cars based on fuel efficiency. This ranking is based on each model's highest-rated combined MPG figure to determine the best gas mileage luxury midsize cars.
The average fuel efficiency for a luxury midsize car is 24 MPG, and 13 models earn that figure or better for their highest-rated combined MPG model. A luxury midsize car with less than 24 combined MPG is below the segment average and may not be a good model for consumers seeking to reduce or manage their fuel consumption.
- Combined MPG Max 30 mpg
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 8.2 / 10
- Value Retention 6.9 / 10
- Safety 8.0 / 10
- Combined MPG Max 28 mpg
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 9.2 / 10
- Value Retention 7.8 / 10
- Safety 10 / 10
- Combined MPG Max 27 mpg
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 8.3 / 10
- Value Retention 7.3 / 10
- Safety 10 / 10
- Combined MPG Max 27 mpg
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability Coming soon
- Value Retention 7.1 / 10
- Safety 10 / 10
- Combined MPG Max 26 mpg
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 9.0 / 10
- Value Retention 7.9 / 10
- Safety 9.0 / 10
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 8.3 / 10
- Value Retention 6.9 / 10
- Safety 10 / 10
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 7.7 / 10
- Value Retention 6.9 / 10
- Safety Not Available
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 7.2 / 10
- Value Retention 7.5 / 10
- Safety 10 / 10
- Combined MPG Max 25 mpg
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 7.7 / 10
- Value Retention 7.6 / 10
- Safety Not Available
- Combined MPG Max 25 mpg
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 5.9 / 10
- Value Retention 7.3 / 10
- Safety 9.0 / 10
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 7.2 / 10
- Value Retention 7.0 / 10
- Safety Not Available
- Combined MPG Max 24 mpg
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability Coming soon
- Value Retention 7.5 / 10
- Safety Not Available
- Combined MPG Max 24 mpg
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability Coming soon
- Value Retention 7.0 / 10
- Safety Not Available
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 7.6 / 10
- Value Retention 7.1 / 10
- Safety Not Available
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 7.3 / 10
- Value Retention 7.1 / 10
- Safety Not Available
- Combined MPG Max 21 mpg
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability Coming soon
- Value Retention 7.1 / 10
- Safety Not Available
- Combined MPG Max 20 mpg
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 5.9 / 10
- Value Retention 6.6 / 10
- Safety Not Available
- Combined MPG Max 18 mpg
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 7.0 / 10
- Value Retention 8.2 / 10
- Safety Not Available
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 7.6 / 10
- Value Retention 7.1 / 10
- Safety Not Available
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability Coming soon
- Value Retention 7.0 / 10
- Safety Not Available
Lincoln MKZ
- Combined MPG Max Not Available
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 8.5 / 10
- Value Retention 7.3 / 10
- Safety 10 / 10
Lexus GS 300
- Combined MPG Max Not Available
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 9.1 / 10
- Value Retention 7.8 / 10
- Safety Not Available
Lexus GS 350
- Combined MPG Max Not Available
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 9.0 / 10
- Value Retention 7.7 / 10
- Safety Not Available
Cadillac CTS
- Combined MPG Max Not Available
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 7.9 / 10
- Value Retention 6.9 / 10
- Safety 10 / 10
Lexus GS F
- Combined MPG Max Not Available
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability 8.1 / 10
- Value Retention 7.8 / 10
- Safety Not Available
Buick Regal Sportback
- Combined MPG Max Not Available
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability Coming soon
- Value Retention 7.6 / 10
- Safety Not Available
BMW M6
- Combined MPG Max Not Available
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability Coming soon
- Value Retention 7.0 / 10
- Safety Not Available
INFINITI Q70L
- Combined MPG Max Not Available
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability Coming soon
- Value Retention 7.0 / 10
- Safety Not Available
INFINITI Q70
- Combined MPG Max Not Available
iSeeCars Best Car Rankings are calculated based on an analysis of data from over 12 million cars that assesses how long each vehicle lasts and how well it retains its value over time, along with safety data from the National Highway Traffic Safety Association
See how we rank these cars- Reliability Coming soon
- Value Retention 6.9 / 10
- Safety 10 / 10
Related Rankings
How We Rank These Cars
The iSeeCars "Best Gas Mileage" lists rank cars, trucks and SUVs based on the highest mpg and most fuel-efficient drivetrain for each vehicle.
Along with the Best Gas Mileage scores, the lists show additional iSeeCars scores because we believe other factors should be taken into account to find the best overall vehicle. If there is a tie in mpg between vehicles, we use the overall iSeeCars Score to break the tie.
The overall iSeeCars Score is an analysis of three factors: reliability, resale value and safety. It is calculated based on the latest research and analysis by our data science team. The data analysis comes from over 12 million new and used vehicles in our Longest-Lasting Cars and 5-Year Depreciation Studies, combined with NHTSA and IIHS Safety Ratings.
Vehicles are scored in three categories:
Reliability
The reliability score represents an analysis of iSeeCars' proprietary research on the longest-lasting vehicles.
Value Retention
The value retention score is based on our data science team's statistical analysis and prediction of 5-year depreciation from MSRP to determine which cars hold their value best, using US Bureau of Labor Statistics data to adjust for inflation.
Safety
The safety score is calculated based on the last five years of crash test ratings from the National Highway Traffic Safety Administration (NHTSA) and incorporates the latest Top Safety Pick information from the Insurance Institute for Highway Safety (IIHS).