Mercedes-Benz E-Class vs. Audi A6

iSeeCars' unbiased and data-driven comparison of the Mercedes-Benz E-Class and Audi A6 contrasts the two cars across a broad spectrum of vehicle specifications to determine which car is better. In addition to comparing pricing and specs, iSeeCars uses all the ratings, rankings, and insights from its comprehensive analyses of each vehicle model, including calculations of reliability, safety, depreciation, value retention, and the vehicle's projected lifetime recalls (based on analyzing over 25 billion data points). This in-depth evaluation is used to identify which vehicle represents a better overall choice for shoppers who are considering both the Mercedes-Benz E-Class and the Audi A6.

When comparing the Mercedes-Benz E-Class's and the Audi A6's specifications and ratings, the Mercedes-Benz E-Class has the advantage in the areas of fuel efficiency, reliability, resale value, interior volume and overall quality score. The Audi A6 has the advantage in the areas of new vehicle base pricing, typical lower range of pricing for one- to five-year-old used cars, and base engine power. Based on this comparison of the Mercedes-Benz E-Class's and the Audi A6's specifications and ratings, the Mercedes-Benz E-Class is a better car than the Audi A6.

Pricing: A used 2025 Mercedes-Benz E-Class ranges from $56,882 to $77,353 while a used 2025 Audi A6 is priced between $47,998 to $71,140. For a new model, the Mercedes-Benz E-Class's price is between $64,852 and $86,269, with the Audi A6 priced between $59,135 and $78,929.

Resale/Retained Value: Looking at the 5-year depreciation rate for both models, the Mercedes-Benz E-Class loses 56.9 percent of its value and the Audi A6 loses 60.9 percent of its value. This means the Mercedes-Benz E-Class retains 4 percentage points more of its value and has the advantage of higher resale value versus the Audi A6.

Quality Rating: The iSeeCars Overall Quality rating for the Mercedes-Benz E-Class is 8.2 out of 10 while the Audi A6's quality rating is 7.5 out of 10. This results in the Mercedes-Benz E-Class being ranked 2 out of 24 Best Luxury Midsize Cars and the Audi A6 being ranked 9 out of 24.

Reliability Rating: iSeeCars’ Reliability Rating for the Mercedes-Benz E-Class is 8.2 out of 10. For the Audi A6 the reliability rating is 7.5 out of 10. This gives the Mercedes-Benz E-Class a slight advantage in reliability compared to the Audi A6.

Engine Power and Fuel Efficiency Comparison: For engine performance, the Mercedes-Benz E-Class’s base engine makes 255 horsepower, and the Audi A6 base engine makes 261 horsepower. The E-Class is rated to deliver an average of 28 miles per gallon, with a highway range of 574 miles. The A6 is rated to deliver an average of 26 miles per gallon, with a highway range of 598 miles.This gives the Mercedes-Benz E-Class the advantage in fuel efficiency and the Audi A6 the advantage in maximum range. Both models use premium unleaded.

Passenger Space Comparison: While both models are midsize cars, the Mercedes-Benz E-Class has the advantage of offering more interior volume, reflected in more front leg room and rear shoulder room. The Audi A6 has the advantage in the areas of front head room, rear head room, rear leg room, and cargo space. The Mercedes-Benz E-Class and Audi A6 are comparable in regards to front shoulder room.

Safety Ratings: When comparing crash test ratings from NHTSA, both the Mercedes-Benz E-Class and the Audi A6 have the same average safety rating of 5 out of 5 Stars.