Lexus IS 350 vs. Mercedes-Benz C-Class

iSeeCars' unbiased and data-driven comparison of the Lexus IS 350 and Mercedes-Benz C-Class contrasts the two cars across a broad spectrum of vehicle specifications to determine which car is better. In addition to comparing pricing and specs, iSeeCars uses all the ratings, rankings, and insights from its comprehensive analyses of each vehicle model, including calculations of reliability, safety, depreciation, value retention, and the vehicle's projected lifetime recalls (based on analyzing over 25 billion data points). This in-depth evaluation is used to identify which vehicle represents a better overall choice for shoppers who are considering both the Lexus IS 350 and the Mercedes-Benz C-Class.

In comparing the Lexus IS 350's and the Mercedes-Benz C-Class's specifications and ratings, the Lexus IS 350 has the advantage in the areas of new vehicle base pricing, reliability, resale value and base engine power. The Mercedes-Benz C-Class has the advantage in the areas of typical lower range of pricing for one- to five-year-old used cars, and fuel efficiency, interior volume and overall quality score. Based on this comparison of the Lexus IS 350's and the Mercedes-Benz C-Class's specifications and ratings, the two cars are fairly comparable.

Pricing: A used 2025 Lexus IS 350 ranges from $42,935 to $56,980 while a used 2025 Mercedes-Benz C-Class is priced between $41,991 to $59,895. For a new model, the Lexus IS 350's price is between $46,323 and $56,587, with the Mercedes-Benz C-Class priced between $50,050 and $69,405.

Resale/Retained Value: Looking at the 5-year depreciation rate for both models, the Lexus IS 350 loses 39.2 percent of its value and the Mercedes-Benz C-Class loses 52.5 percent of its value. This means the Lexus IS 350 retains 13.3 percentage points more of its value and has the advantage of higher resale value versus the Mercedes-Benz C-Class.

Quality Rating: The iSeeCars Overall Quality rating for the Lexus IS 350 is 8.3 out of 10 while the Mercedes-Benz C-Class' quality rating is 8.4 out of 10. This results in the Lexus IS 350 being ranked 2 out of 36 Best Luxury Small Cars and the Mercedes-Benz C-Class being ranked 1 out of 36.

Reliability Rating: iSeeCars’ Reliability Rating for the Lexus IS 350 is 8.5 out of 10. For the Mercedes-Benz C-Class the reliability rating is 7.5 out of 10. This gives the Lexus IS 350 an advantage in reliability compared to the Mercedes-Benz C-Class.

Engine Power and Fuel Efficiency Comparison: For engine performance, the Lexus IS 350’s base engine makes 311 horsepower, and the Mercedes-Benz C-Class base engine makes 255 horsepower. The IS 350 is rated to deliver an average of 23 miles per gallon, with a highway range of 487 miles. The C-Class is rated to deliver an average of 29 miles per gallon, with a highway range of 609 miles. This gives the Mercedes-Benz C-Class the fuel efficiency and maximum range advantage over the Lexus IS 350. Both models use premium unleaded.

Passenger Space Comparison: While both models are compact cars, the Mercedes-Benz C-Class has the advantage of offering more interior volume, reflected in more front head room, front shoulder room, rear head room, rear shoulder room, rear leg room, and cargo space. The Lexus IS 350 has the advantage in the area of front leg room.

Safety Ratings: When comparing crash test ratings from NHTSA, both the Lexus IS 350 and the Mercedes-Benz C-Class have the same average safety rating of 5 out of 5 Stars.