Lexus IS 350 vs. Lexus RX 450h
iSeeCars' unbiased and data-driven comparison of the Lexus IS 350 and Lexus RX 450h contrasts the two cars across a broad spectrum of vehicle specifications to determine which car is better. In addition to comparing pricing and specs, iSeeCars uses all the ratings, rankings, and insights from its comprehensive analyses of each vehicle model, including calculations of reliability, safety, depreciation, value retention, and the vehicle's projected lifetime recalls (based on analyzing over 25 billion data points). This in-depth evaluation is used to identify which vehicle represents a better overall choice for shoppers who are considering both the Lexus IS 350 and the Lexus RX 450h.
When comparing the Lexus IS 350's and the Lexus RX 450h's specifications and ratings, the Lexus IS 350 has the advantage in the areas of typical lower range of pricing for one- to five-year-old used cars, resale value, overall quality score and base engine power. The Lexus RX 450h has the advantage in the areas of fuel efficiency, reliability and interior volume. Based on this comparison of the Lexus IS 350's and the Lexus RX 450h's specifications and ratings, the Lexus IS 350 is a better car than the Lexus RX 450h.
Pricing: A used 2022 Lexus IS 350 ranges from $36,029 to $45,900 while a used 2022 Lexus RX 450h is priced between $39,998 to $54,414.
Resale/Retained Value: Looking at the 5-year depreciation rate for both models, the Lexus IS 350 loses 39.2 percent of its value and the Lexus RX 450h loses 40.6 percent of its value. This means the Lexus IS 350 retains 1.3 percentage points more of its value and has the advantage of higher resale value versus the Lexus RX 450h.
Quality Rating: The iSeeCars Overall Quality rating for the Lexus IS 350 is 8.3 out of 10 while the Lexus RX 450h's quality rating is 8.1 out of 10. This results in the Lexus IS 350 being ranked 2 out of 35 Best Luxury Small Cars and the Lexus RX 450h being ranked 3 out of 31 Best Luxury Hybrid SUVs.
Reliability Rating: iSeeCars’ Reliability Rating for the Lexus IS 350 is 8.5 out of 10. For the Lexus RX 450h the reliability rating is 8.6 out of 10. This gives the Lexus RX 450h a slight advantage in reliability compared to the Lexus IS 350.
Engine Power and Fuel Efficiency Comparison: For engine performance, the Lexus IS 350’s base engine makes 311 horsepower, and the Lexus RX 450h base engine makes 308 horsepower. The IS 350 is rated to deliver an average of 23 miles per gallon, with a highway range of 487 miles. The RX 450h is rated to deliver an average of 30 miles per gallon, with a highway range of 482 miles.This gives the Lexus RX 450h the advantage in fuel efficiency and the Lexus IS 350 the advantage in maximum range. Both models use premium unleaded.
Passenger Space Comparison: The Lexus RX 450h, a hybrid SUV, has the advantage of offering more interior volume, reflected in more front head room, front shoulder room, rear head room, rear shoulder room, rear leg room, and cargo space. The Lexus IS 350, a compact car, has the advantage in the area of front leg room.
Safety Ratings: When comparing crash test ratings from NHTSA, the Lexus IS 350 has higher safety ratings than the Lexus RX 450h, with an average rating of 5 out of 5 Stars compared to 4.45 out of 5 Stars.
New Car Pricing
Asking Price:
-
Starting MSRP:
43550
Category Avg Starting MSRP:
(Luxury Compact Cars)
46042
Category Starting MSRP Range:
(Luxury Compact Cars)
27300 - 76200
New Car Pricing
Asking Price:
-
Starting MSRP:
48720
Category Avg Starting MSRP:
(Luxury Hybrid Midsize SUVs)
61958
Category Starting MSRP Range:
(Luxury Hybrid Midsize SUVs)
48720 - 83300
Used Car Pricing
Avg Used Car Price:
41148
Price Range:
36029 - 45900
Category Avg Price:
(Luxury Compact Cars)
38447
Category Avg Price Range:
(Luxury Compact Cars)
24836 - 75567
# Used Cars for Sale Nationally:
123
Avg Mileage of Used Cars for Sale:
50495
# Good or Great Deals:
45
Used Car Pricing
Avg Used Car Price:
47423
Price Range:
39998 - 54414
Category Avg Price:
(Luxury Hybrid Midsize SUVs)
56642
Category Avg Price Range:
(Luxury Hybrid Midsize SUVs)
47423 - 82654
# Used Cars for Sale Nationally:
77
Avg Mileage of Used Cars for Sale:
61261
# Good or Great Deals:
33
Lexus IS 350 Scores & Rankings
Overall Score:
8.3 / 10
Reliability:
8.5 / 10
Retained Value:
8.5 / 10
Safety:
8.0 / 10
Lexus RX 450h Scores & Rankings
Overall Score:
8.1 / 10
Reliability:
8.6 / 10
Retained Value:
8.4 / 10
Safety:
7.4 / 10
iSeeCars Reliability Insights for Lexus IS 350
Remaining Life Expectancy (years):
17.1
Typical Category Remaining Life Expectancy:
(Luxury Compact Cars)
9.2
Category Remaining Life Expectancy Range:
(Luxury Compact Cars)
6.5 - 17.1
Chance of Reaching 200k Miles for a New Car:
0.517
iSeeCars Reliability Insights for Lexus RX 450h
Remaining Life Expectancy (years):
15.1
Typical Category Remaining Life Expectancy:
(Luxury Hybrid Midsize SUVs)
15.1
Category Remaining Life Expectancy Range:
(Luxury Hybrid Midsize SUVs)
15.1 - 15.1
Chance of Reaching 200k Miles for a New Car:
0.44
Expected 30-year Lifetime Recalls
Expected Lifetime Recalls:
1.0269672412341497
Typical Category Recalls:
(Luxury Compact Cars)
2.5
Category Range for Recalls:
(Luxury Compact Cars)
1.0 - 10.7
Expected 30-year Lifetime Recalls
Expected Lifetime Recalls:
1.0995134697947773
Typical Category Recalls:
(Luxury Hybrid Midsize SUVs)
3.4
Category Range for Recalls:
(Luxury Hybrid Midsize SUVs)
1.1 - 7.3
Lexus IS 350 Rankings
Ranking
1 out of / 35Ranking
2 out of / 35Ranking
2 out of / 35Ranking
2 out of / 35Ranking
3 out of / 35Ranking
3 out of / 30Ranking
5 out of / 35Ranking
11 out of / 30Ranking
21 out of / 35Ranking
22 out of / 35Ranking
26 out of / 35Ranking
28 out of / 35Lexus RX 450h Rankings
Ranking
1 out of / 31Ranking
1 out of / 28Ranking
1 out of / 11Ranking
1 out of / 11Ranking
3 out of / 31Ranking
3 out of / 31Ranking
3 out of / 28Ranking
3 out of / 11Ranking
4 out of / 31Ranking
4 out of / 28Ranking
4 out of / 11Ranking
7 out of / 11Ranking
7 out of / 11Ranking
8 out of / 28Ranking
8 out of / 11Ranking
9 out of / 31Ranking
9 out of / 11Ranking
11 out of / 11Ranking
12 out of / 31Ranking
12 out of / 28Ranking
15 out of / 31Ranking
15 out of / 31Ranking
15 out of / 28Ranking
15 out of / 28Ranking
16 out of / 28Ranking
18 out of / 31Ranking
19 out of / 31Ranking
26 out of / 28Ranking
29 out of / 31Available Body Styles
Sedan
Available Body Styles
SUV
Available Drivetrain Options
Gasoline
Available Drivetrain Options
Hybrid
Lexus IS 350 Trim Levels
F SPORT
Lexus RX 450h Trim Levels
Base, F SPORT, F SPORT Handling
Warranty Information
Warranty, Bumper-to-Bumper:
4 years / 50000 miles
Warranty, Powertrain:
6 years / 70000 miles
Warranty, Roadside Assistance:
4 years
Warranty Information
Warranty, Bumper-to-Bumper:
4 years / 50000 miles
Warranty, Powertrain:
6 years / 70000 miles
Warranty, Roadside Assistance:
4 years
Safety Ratings
NHTSA Safety Rating (last 5 year average):
5 out of 5 Stars
2026 NHTSA Overall Rating:
5 out of 5 Stars
2026 NHTSA Front Crash Overall Rating:
4 out of 5 Stars
2026 NHTSA Side Crash Overall Rating:
5 out of 5 Stars
2026 NHTSA Rollover Rating:
5 out of 5 Stars
IIHS Safety Rating:
Not yet available
Safety Ratings
NHTSA Safety Rating (last 5 year average):
4.45 out of 5 Stars
2026 NHTSA Overall Rating:
4 out of 5 Stars
2026 NHTSA Front Crash Overall Rating:
4 out of 5 Stars
2026 NHTSA Side Crash Overall Rating:
5 out of 5 Stars
2026 NHTSA Rollover Rating:
4 out of 5 Stars
IIHS Safety Rating:
Not yet available
Base Drivetrain Specs
Horsepower:
311 hp @ 6400 rpm
Torque:
280 foot-lbs @ 4800 rpm
Power-to-Weight Ratio (higher is better):
0.083 hp per pound
Towing capacity:
Not yet available
Base Drivetrain Specs
Horsepower:
308 hp @ 6000 rpm
Torque:
Not yet available
Power-to-Weight Ratio (higher is better):
0.065 hp per pound
Towing capacity:
Not yet available
Engine Specifications
Engine Size:
3.5 liters
Engine Configuration:
V
Number of Cylinders:
6
Transmission:
Automatic
Standard/Optional Drivetrain Type:
RWD / AWD
EPA Fuel Economy
(City/Highway/Combined MPG):
20 / 28 / 23
Range (city/hwy):
348 / 487 miles
Recommended Fuel Type:
Premium Unleaded
Engine Specifications
Engine Size:
3.5 liters
Engine Configuration:
V
Number of Cylinders:
6
Transmission:
Continuously Variable Transmission (CVT Automatic)
Standard/Optional Drivetrain Type:
AWD
EPA Fuel Economy
(City/Highway/Combined MPG):
31 / 28 / 30
Range (city/hwy):
533 / 482 miles
Recommended Fuel Type:
Premium Unleaded
Standard/Optional Features
Adaptive Cruise Control:
Standard
Alloy wheels:
Standard
Android Auto:
Standard
Apple CarPlay:
Standard
Bench Seats:
Standard
Bluetooth:
Standard
Cooled/Ventilated Seats:
Standard
Heated Seats
Standard
Heated Steering Wheel:
Standard
Internet Radio:
Standard
Keyless Entry:
Standard
Keyless Ignition:
Standard
Leather Upholstery:
Standard
Navigation System:
Standard
Paddle Shifters:
Standard
Power outlet:
Standard
Roadside assistance:
Standard
Satellite radio:
Standard
Voice Recognition:
Standard
Wifi:
Standard
Parking Sensors:
Available
Sunroof/Moonroof:
Available
Air Suspension:
N/A
Automatic Parking:
N/A
Captain's seat:
N/A
Front Bench Seats:
N/A
Massage Seats:
N/A
Panoramic Sunroof/Moonroof
N/A
Power Lift Gate:
N/A
Quad Seats:
N/A
Roof Rack:
N/A
Trailer Hitch:
N/A
Wireless Smartphone Charging:
N/A
Standard/Optional Features
Adaptive Cruise Control:
Standard
Alloy wheels:
Standard
Android Auto:
Standard
Apple CarPlay:
Standard
Bench Seats:
Standard
Bluetooth:
Standard
Cooled/Ventilated Seats:
Available
Heated Seats
Available
Heated Steering Wheel:
Available
Internet Radio:
Standard
Keyless Entry:
Standard
Keyless Ignition:
Standard
Leather Upholstery:
Standard
Navigation System:
Standard
Paddle Shifters:
Standard
Power outlet:
Standard
Roadside assistance:
Standard
Satellite radio:
Standard
Voice Recognition:
Standard
Wifi:
Standard
Parking Sensors:
Available
Sunroof/Moonroof:
Available
Air Suspension:
N/A
Automatic Parking:
N/A
Captain's seat:
N/A
Front Bench Seats:
N/A
Massage Seats:
N/A
Panoramic Sunroof/Moonroof
N/A
Power Lift Gate:
Standard
Quad Seats:
N/A
Roof Rack:
Available
Trailer Hitch:
N/A
Wireless Smartphone Charging:
Available
Safety Features
Backup camera:
Standard
Blind Spot Monitoring:
Standard
Forward Collision Warning:
Standard
Lane Departure Warning:
Standard
Lane Keeping Assist:
Standard
Pedestrian Detection:
Standard
Rear Cross-Traffic Alert:
Standard
360-Degree Camera:
N/A
Driver Attention Monitoring:
N/A
Rear Seat Reminder:
N/A
Safety Features
Backup camera:
Standard
Blind Spot Monitoring:
Standard
Forward Collision Warning:
Standard
Lane Departure Warning:
Standard
Lane Keeping Assist:
Standard
Pedestrian Detection:
Standard
Rear Cross-Traffic Alert:
Standard
360-Degree Camera:
N/A
Driver Attention Monitoring:
N/A
Rear Seat Reminder:
N/A
Interior Dimensions
Front Head Room:
38.2 inches
Front Leg Room:
44.8 inches
Front Shoulder Room:
55.9 inches
Rear Head Room:
36.9 inches
Rear Leg Room:
32.2 inches
Rear Shoulder Room:
53.4 inches
Cargo Space:
10.8 cubic feet
Cargo Space, 2nd-row seat folded down:
Not yet available
Overall Interior Volume:
90.2 cubic feet
Interior Dimensions
Front Head Room:
39.4 inches
Front Leg Room:
44.1 inches
Front Shoulder Room:
57.8 inches
Rear Head Room:
38.2 inches
Rear Leg Room:
38 inches
Rear Shoulder Room:
57.6 inches
Cargo Space:
16 cubic feet
Cargo Space, 2nd-row seat folded down:
32.6 cubic feet
Overall Interior Volume:
114.1 cubic feet
Exterior Dimensions
Curb Weight:
3748 lbs
Width:
72.4 inches
Height:
56.5 inches
Length:
185.4 inches
Wheelbase:
110.2 inches
Ground Clearance:
5.5 inches
Exterior Dimensions
Curb Weight:
4740 lbs
Width:
74.6 inches
Height:
67.7 inches
Length:
192.5 inches
Wheelbase:
109.8 inches
Ground Clearance:
8.2 inches
Standard Wheel/Tire Information
Wheel Size:
19.0 x 8.5 inches
Wheel Type:
aluminum alloy
Tire Size:
235/40R19
Standard Wheel/Tire Information
Wheel Size:
18.0 x 8.0 inches
Wheel Type:
aluminum alloy
Tire Size:
235/65R18
Exterior Colors
Black
Caviar
Blue
Grecian Water / Ultrasonic Blue Mica 2.0
Gray
Cloudburst Gray
Red
Infrared
Silver
Atomic Silver / Iridium
White
Ultra White
Green
Not available
Exterior Colors
Black
Caviar
Blue
Nightfall Mica
Gray
Nebula Gray Pearl
Red
Matador Red Mica
Silver
Atomic Silver
White
Eminent White Pearl
Green
Nori Green Pearl
Interior Colors
Black
Black w/Ash Trim / Black w/Black Geometric Trim
Red
Circuit Red w/Ash Trim / Circuit Red w/Black Geometric Trim
White
White w/Black Geometric Trim
Beige
Not available
Brown
Not available
Gray
Not available
Interior Colors
Black
Black w/Gray Sapele Wood and Aluminum Trim / Black w/Matte Walnut Trim / Black w/Open Pore Black Walnut Trim and White Accents and Gray Stitching / Black w/Striated Black Trim
Red
Not available
White
Not available
Beige
Parchment w/Gray Sapele Wood and Aluminum Trim / Parchment w/Matte Bamboo Trim / Parchment w/Striated Black Trim
Brown
Glazed Caramel w/Gray Sapele Wood and Aluminum Trim / Glazed Caramel w/Matte Walnut Trim
Gray
Birch w/Gray Sapele Wood and Aluminum Trim / Birch w/Matte Walnut Trim / Birch w/Striated Black Trim
